By Navnit Shah,Harpreet Sandhu,Duk Soon Choi,Hitesh Chokshi,A. Waseem Malick
This quantity bargains a finished advisor at the thought and perform of amorphous good dispersions (ASD) for dealing with demanding situations linked to poorly soluble medicinal drugs. In twenty-three inclusive chapters, the booklet examines thermodynamics and kinetics of the amorphous kingdom and amorphous stable dispersions, ASD applied sciences, excipients for stabilizing amorphous stable dispersions resembling polymers, and ASD production applied sciences, together with spray drying, scorching soften extrusion, fluid mattress layering and solvent-controlled micro-precipitation know-how (MBP). every one expertise is illustrated via particular case reviews. moreover, devoted sections conceal analytical instruments and applied sciences for characterization of amorphous good dispersions, the prediction of long term balance, and the improvement of appropriate dissolution equipment and regulatory facets. The ebook additionally highlights destiny applied sciences at the horizon, akin to supercritical fluid processing, mesoporous silica, KinetiSol®, and using non-salt-forming natural acids and amino acids for the stabilization of amorphous systems.
Amorphous strong Dispersions: idea and perform is a necessary connection with pharmaceutical scientists drawn to constructing bioavailable and therapeutically powerful formulations of poorly soluble molecules to be able to develop those applied sciences and increase larger medicinal drugs for the future.
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Amorphous Solid Dispersions: Theory and Practice (Advances in Delivery Science and Technology) by Navnit Shah,Harpreet Sandhu,Duk Soon Choi,Hitesh Chokshi,A. Waseem Malick